Raised in
Mouse
Verified reactivity
Human
Available ordering format
Liquid
Protein number
P42574
Clonality
Monoclonal
Clone
AM1 4 , IgG
Molecular weight (expected | аpparent)
see datasheet
TAIR number
Refer to NCBI
Possible reactivity
to be determined
Storage condition
Store at -20°C.
Verified applications
Western Blot (WB)
Purification
Protein A/G purified.
Connected products
anti-mouse secondary antibodies
Immunogen
Recombinant human Caspase-3 protein. UniProt: P42574
How to reconstitute
See included datasheet or contact our support service
References
To be added when available, antibody released in November 2016.
Recommended dilutions for use
Optimal concentrations should be determined by serial dilutions.
Notes
Provided in phosphate buffered saline, contains 0.08% sodium azide.
No reactivity
No confirmed exceptions from predicted reactivity known at the moment.
Description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
Scientific context
Caspase-3 is involved in the activation cascade of caspases, this cascade is responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 belongs to the group of effector caspases that are involved in the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others._x000B_
