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CASP3, Caspase-3

Size

CASP3, Caspase-3

100 µg

Catalog no.

AS16 4001

Price

447 EUR

Buy CASP3, Caspase-3 at gentaur.com

Raised in

Mouse

Verified reactivity

Human

Available ordering format

Liquid

Protein number

P42574

Clonality

Monoclonal

Clone

AM1 4 , IgG

Molecular weight (expected | аpparent)

see datasheet

TAIR number

Refer to NCBI

Possible reactivity

to be determined

Storage condition

Store at -20°C.

Verified applications

Western Blot (WB)

Purification

Protein A/G purified.

Connected products

anti-mouse secondary antibodies

Supplementary information

Contact Gentaur support center at info@gentaur.com

Immunogen

Recombinant human Caspase-3 protein. UniProt: P42574

How to reconstitute

See included datasheet or contact our support service

References

To be added when available, antibody released in November 2016.

Recommended dilutions for use

Optimal concentrations should be determined by serial dilutions.

Notes

Provided in phosphate buffered saline, contains 0.08% sodium azide.

No reactivity

No confirmed exceptions from predicted reactivity known at the moment.

Description

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.

Scientific context

Caspase-3 is involved in the activation cascade of caspases, this cascade is responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 belongs to the group of effector caspases that are involved in the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others._x000B_