Tested Applications WB
Gene ID number 836
Swiss Prot P42574
French translation anticorps
Immunogen range 30-55/277
Subcellular location Cytoplasm
Concentration 1ug per 1ul
Recommended dilutions WB(1:100-1000)
Cross reactivity Human, Mouse, Rat
Category Primary Antibodies
Modification site(s) Unmodified antibody
Clonality Polyclonal antibody
Clone number Polyclonal antibody
Target Antigen Caspase-3 p17 subunit
Also known as Caspase-3 p17 subunit PAb
Purification method This antibody was purified via Protein A.
Long name Caspase-3 p17 subunit Primary Polyclonal Antibody
Specificity This is a highly specific antibody against Caspase-3 p17 subunit.
Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human caspase-3 p17 subunit
Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Description Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
Synonym names Caspase-3 subunit p17; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cleavage protease; SCA 1; SCA1; SREBP cleavage activity 1; Yama; CASP3_HUMAN; Caspase-3; CASP-3; Apopain; Protein Yama; SREBP cleavage activity 1; SCA-1.
Background of the target antigen Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.