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Caspase-3 Antibody (phospho-S26)

Size

Caspase-3 Antibody (phospho-S26)

0.08 ml

Catalog no.

F48685-0.08ML

Price

199 EUR

Buy Caspase-3 Antibody (phospho-S26) at gentaur.com

Uniprot #

P70677

Category

Antibody

Tested applications

DB, ELISA

French translation

anticorps

Conjugation

Unconjugated

Recommended dilutions

Dot blot: 1:500

Purity

Antigen affinity

Clone

Polyclonal antibody

Recognised antigen

Caspase-3 (phospho-S26)

Form

Antigen affinity purified

Clonality

Polyclonal (rabbit origin)

Host animal

Rabbit (Oryctolagus cuniculus)

Concentration

In 1X PBS pH 7.4 with 0.09% sodium azide

Intented use

This phospho-Caspase-3 antibodyis to be used only for research purposes and not for diagnostics..

Notes

Titration of the phospho-Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Properties

If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Species reactivity

Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.

Immunogen

This phospho-Caspase-3 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS26 of mouse CASP3.

Additional description

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.

Storage

Aliquot the phospho-Caspase-3 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].