Is it cell-permeable?
Y
Is this a salt?
No
Peptide sequence
N/A
Supplied with
N/A
Tissue
cell
Storage condition
-20°C
Molecular weight
324.40
Shipping condition
Gel Pack
Maximum time for storage
36 months
CAS number
220509-74-0
Physical appearance
Yellow solid
Category
Biochemicals
Purification
≥97% by HPLC
Reconstitute instructions
DMSO (~ 200 mg/ml)
Molecular formula
C₁₄H₁₆N₂O₅S
Storage instructions
Protect from air and light
Other name
5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
Description
Caspase-3/7 inhibitor is a potent, cell-permeable, specific, and reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). It acts as a weaker inhibitor of caspase-9 (Ki = 3.1 µM).
Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
