Is this a salt?
No
Supplied with
N/A
Is it cell-permeable?
Yes
CAS number
N/A
Reconstitute instructions
DMSO
Tissue
cell
Storage condition
-20°C
Molecular weight
799.77
Shipping condition
gel pack
Maximum time for storage
12 months
Purification
>90% by HPLC
Category
Biochemicals
Physical appearance
Off-white solid
Storage instructions
Protect from moisture
Molecular formula
C₃₈H₄₃F₂N₅O₁₂
Other name
Q-DEVD-Oph, Q-Asp-Glu-Val-Asp-Oph
Peptide sequence
Quinolyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-OPh
Description
A second-generation capase-3 inhibitor that is potent, cell permeable, irreversible and nontoxic.
Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
