Caspase-3 Inhibitor Z-DEVD-FMK for cell activation

Size

Caspase-3 Inhibitor Z-DEVD-FMK for cell activation

100 µl

Catalog no.

1009-100

Price

186 EUR

Buy Caspase-3 Inhibitor Z-DEVD-FMK for cell activation at gentaur.com

Is this a salt?

No

Reconstitute instructions

N/A

Is it cell-permeable?

Yes

CAS number

N/A

Tissue

cell

Molecular weight

668.7

Storage condition

-20°C

Physical appearance

Liquid

Shipping condition

gel pack

Maximum time for storage

6-12 months

Purification

>98% by HPLC

Supplied with

In DMSO (2 mM)

Category

Caspase Inhibitor

Molecular formula

C₃₀H₄₁FN₄O₁₂

Storage instructions

Protect from light and moisture

Peptide sequence

Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK

Other name

Z-DEVD-FMK, Caspase-3 inhibitor, Z-DEVD fluoromethylketone

Description

A synthetic peptide inhibitor that irreversibly inhibits caspase-3 and related protease/caspase activity and blocks apoptosis. DEVD is the specific recognition sequence found in poly (ADP-ribose) polymerase (PARP). The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Additional description

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.