Is this a salt?
No
Reconstitute instructions
N/A
Is it cell-permeable?
Yes
CAS number
N/A
Tissue
cell
Molecular weight
668.7
Storage condition
-20°C
Physical appearance
Liquid
Shipping condition
gel pack
Maximum time for storage
6-12 months
Purification
>98% by HPLC
Supplied with
In DMSO (10 mM)
Category
Caspase Inhibitor
Molecular formula
C₃₀H₄₁FN₄O₁₂
Storage instructions
Protect from light and moisture
Peptide sequence
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Other name
Z-DEVD-FMK, Caspase-3 inhibitor, Z-DEVD fluoromethylketone
Description
A synthetic peptide inhibitor that irreversibly inhibits caspase-3 and related protease/caspase activity and blocks apoptosis. DEVD is the specific recognition sequence found in poly (ADP-ribose) polymerase (PARP). The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.